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April 24, 2003
Medicure's Announces Third Quarter/Nine-Month Financial Results

WINNIPEG, Manitoba - (April 24, 2003) - Medicure Inc. (TSX:MPH), a cardiovascular drug discovery and development company, today reported financial results for the three-month and nine-month periods ending February 28, 2003. Unless otherwise stated, the dollar values quoted herein represent Canadian dollars.

Research and development expenditures during the third quarter ended February 28, 2003 were $584,000 as compared to $585,000 for the same quarter in 2002. The year- to- date research and development expenditures were $2,515,000, versus $1,929,000 for the nine-month period ended February 28, 2002. This increase is due primarily to the costs associated with the MEND-1 phase II trial, which was successfully completed in the past quarter. The Company anticipates research and development expenditures will increase in fiscal 2004 with the initiation of a Phase II clinical trial in patients undergoing coronary artery bypass graft (CABG) procedures, expected to commence later this calendar year.

MILESTONE ACHIEVED
During the quarter ended February 28, 2003, Medicure achieved a major milestone when the Company announced positive results from its MEND-1 Phase II clinical study. The MEND-1 trial was a proof of principle study to establish the efficacy and safety of Medicure's lead compound, MC-1 as a cardioprotective treatment to reduce damage to the heart associated with acute ischemic and reperfusion injury. Central management was provided by Duke Clinical Research Institute, Durham, NC (DCRI), an international leader in cardiovascular clinical evaluation.

"The results were better than expected, and in fact, exceeded our expectations," stated Albert D. Friesen, Ph.D, Medicure's Chairman, President and Chief Executive Officer. "These findings have provided us with the necessary positive data to proceed with larger, pivotal Phase II trials later this calendar year."

OTHER FINANCIAL RESULTS
Interest and other income for the third quarter ended February 28, 2003 was $68,000 compared to $63,000 for the third quarter ended February 28, 2002. The year-to-date interest and other income is $190,000 compared to $97,000 for the nine-month period ended February 28, 2002. The increase is the result of a higher cash and cash equivalent balance as compared to the same period of the prior year.

General and administrative expenditures for the current quarter were $394,000 compared to $231,000 for the same quarter in 2002. The year-to-date general and administrative expenditures were $950,000 as compared to $686,000 for the nine-month period ended February 28, 2002. The increase is attributable to the internal growth, which has taken place to support the Company's increasing business development and investor relations activities.

As a result of the above noted items, the financial results for the third quarter ended February 28, 2003 include a consolidated net loss from operations of $917,000 or $0.02 per share, compared to a net loss of $792,000 or $0.03 per share for the three month period ended February 28, 2002. The net loss for the nine-month period was $3,296,000 or $0.09 per share, compared to $2,510,000 or $0.10 per share for the nine months ended February 28, 2002. As noted, the increase in operating loss was primarily due to the clinical expenditures associated with the Company's Phase II MEND-1 clinical trial, the enhanced research and development programs and other business development activities.

The Company continues to maintain a solid cash position, with cash and cash equivalents totaling $5,187,000 as of February 28, 2003, versus $8,341,000 as of May 31, 2002, the end of the 2002 fiscal year. In addition, for the current nine month reporting period, Medicure received proceeds of $37,000 from the exercise of options and warrants - this compares to $6,000 for the same period a year ago.

Based on current plans and strategies, the Company believes it has sufficient resources to fund its operation to the end of the third quarter of fiscal 2004, including undertaking a second clinical trial in CABG.

Effective March 1, 2003 all of the issued and outstanding Class A Common Shares (TSX: MPH.A) - totaling 1,280,000 shares - were converted into Common Shares of the Company on the basis of one Common Share for each Class A Common Share in accordance with the Company's Articles of Continuance. The Common Shares and the Class A Common Shares were identical in all respects with the only distinction being that the Class A Common Shares were eligible for the Manitoba Equity Tax Credit which expired on February 28, 2003. As of March 1, 2003 there was no legal distinction between the Company's Common Shares and the Class A Common Shares.

An expanded version of the Management Discussion and Analysis and the financial statements for the quarter are accessible on Medicure's website at www.medicureinc.com.

About Medicure Inc.
Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine including the prevention and treatment of ischemia, ischemic reperfusion injury, and stroke.

This press release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Derek Reimer
Chief Financial Officer

Don Bain
Director of Investor & Public Relations

Medicure Inc.
888-435-2220
204-488-9823 fax
info@medicure.com

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