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March 28, 2003
Medicure, Duke Spotlight MEND-1 Results at the American College of Cardiology Meetings

WINNIPEG, Manitoba - (March 28, 2003) - Medicure Inc. (TSX: MPH), a cardiovascular drug discovery and development company, is pleased to announce that it will co-host a Satellite Symposium at the 52nd Annual Scientific Sessions of the American College of Cardiology in Chicago, Illinois, to announce the positive results of the recently completed phase II MEND-1 clinical study of its lead drug, MC-1. The event will be co-hosted by Duke Clinical Research Institute and will feature a presentation by Dr. James E. Tcheng, MD, F.A.C.C., Associate Professor of Medicine, Duke University Medical Center and the Principal Investigator of the trial.

In addition, Medicure also will host a Conference Call on Tuesday, April 1, 2003, to discuss the MEND-1 Phase II clinical study. Participating on the Conference Call from Medicure's senior management group will be Dr. Albert D. Friesen, PhD., Chairman and Chief Executive Officer, and Dr. Karl-Gunnar Hidinger, PhD., Vice-President, Clinical Development. Also taking part will be Dr. Tcheng, and Dr. David Kandzari, MD, Director, Interventional Cardiology Research, Duke University Medical Centre and a sub-investigator on the MEND-1 clinical trial.

A News Release regarding the MEND-1 clinical trial will be issued in the morning of March 31, 2003, with the Conference Call taking place at 11 a.m. Eastern Standard Time the following day.

SUMMARY OF CONFERENCE CALL

Date of Conference Call: Tuesday, April 1, 2003

Time of Call: 11 a.m. Eastern Standard Time

Dial-in Numbers for 1-877-667-7774 (Toll Free)
Participants: 416-695-6120 (Toronto area participants)

About Medicure Inc.
Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine including the prevention and treatment of ischemia, ischemic reperfusion injury, and stroke.

This press release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Don Bain
Director of Investor & Public Relations
Medicure Inc.
Tel. 888-435-2220/Fax 204-488-9823
info@medicure.com

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