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November 12, 2003
Medicure Strengthens Proprietary Position With Receipt of Eighth USA Patent in the Treatment of Cardiovascular and Related Diseases

WINNIPEG, Manitoba -(November 12, 2003). Medicure Inc. (TSX:MPH), a cardiovascular drug discovery and development company, is pleased to announce that it has been issued patent No. 6,605,612, "Cardioprotective Phosphonates and Malonates", by the US Patent and Trademark Office. The newly issued patent, the Company's eighth, covers composition of matter claims and compound claims in a series of novel therapeutics in the treatment of cardiovascular and related diseases.

Medical uses in this patent include treatment of cerebral and myocardial ischemia, hypertension, myocardial infarction, ischemic reperfusion injury and other metabolic and cardiovascular conditions.

"This new composition of matter patent, developed by Medicure's own team of medical chemists, provides additional protection and strengthens the intellectual properties surrounding Medicure's drug discovery and development efforts," said Albert D. Friesen, PhD, Medicure's President and CEO. "The continued growth of our patent portfolio is a further testament to and corroboration of the novelty of the Company's research and its systematic approach to building value for our shareholders."

The Company's Drug Discovery Program is focused on advancing novel therapeutics to address unmet cardiovascular needs. Through its relationship with CanAm Bioresearch Inc., Medicure has established capabilities in the areas of medicinal chemistry, cardiovascular physiology and drug screening. The objective is create new therapeutics based on MC-1's natural product scaffold whose structural architecture, or scaffold, has been established as safe and active, and provides a powerful guiding principle for development of novel drugs.

About Medicure Inc.
Medicure Inc is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine. The Company's lead drug, MC-1, is focused on the prevention and treatment of ischemia, ischemic reperfusion injury, and stroke. The cardiovascular and stroke market is the largest pharmaceutical sector with annual global sales of over US $70 billion.

The Company's second product candidate, MC-4232, is being targeted for the treatment of hypertension, a common disorder in which blood pressure remains abnormally high. Approximately 73% of the more than 50 million adult Americans who have hypertension, are not adequately treated.

Medicure also has a medicinal chemistry based Drug Discovery program focused on discovery and advancement of novel small molecule, anti-ischemics and anti-thrombotics towards human clinical studies.

This news release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Derek Reimer
Chief Financial Officer

Don Bain
Director of Investor & Public Relations

Medicure Inc.
888-435-2220
204-488-9823 fax
info@medicure.com

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