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January 21, 2004
Gerald McDole, Former CEO of AstraZeneca,
Appointed to Medicure Board of Directors

WINNIPEG, Manitoba - (January 21, 2004) Medicure Inc. (TSX:MPH), a cardiovascular drug discovery and development company, is pleased to announce the appointment of Gerald P. McDole, MBA, former President and Chief Executive Officer of AstraZeneca Canada Inc., to its Board of Directors, effective January 16, 2004. Mr. McDole retired on October 1, 2003 from AstraZeneca Canada, after leading the company and its predecessor, Astra Pharma Inc., for 20 years.

"We are both delighted and honoured to have Mr. McDole join Medicure's team to provide us with the benefit of his extensive background and experience in the pharmaceutical industry," stated Albert D. Friesen, PhD., Medicure's President and CEO. "Mr. McDole brings with him an exceptional level of understanding of the Canadian and international pharmaceutical industry, which will be an important asset to Medicure as we continue to focus on advancing our clinical, business development and drug commercialization programs."

About Gerald McDole
Mr. McDole was named President and CEO of AstraZeneca Canada Inc.'s pharmaceutical operations in 1999 and immediately led the merger of Astra Pharma and Zeneca Pharma Inc. later that year. Prior to this, Mr. McDole was president and CEO of Astra Pharma Inc., a position he assumed in 1985 after having served as Executive Vice-President.

Highly active in a variety of health-related associations, Mr. McDole is a past Chairman of the Board of the Advanced Coronary Treatment (ACT) Foundation and is a past President of the Canadian Foundation for Pharmacy. He is an advisor to both the Institute of Health Economics in Edmonton and the Principal's Advisory Council, University of Toronto at Mississauga, and a former member of the Board of the Canadian Stroke Network.

Mr. McDole was selected for inclusion in the 2002 Canadian Healthcare Marketing Hall of Fame, and in 2002, Canadian Healthcare Manager Magazine recognized him with the Who's Who in Healthcare Award in the pharmaceutical category. He was also presented with the Queen's Golden Jubilee Medal for his contribution to reBOOT Canada. In 1999, the Mississauga Board of Trade recognized Mr. McDole as Businessperson of the Year.

In recognition of Mr. McDole's outstanding contributions to the biotech and pharmaceutical industries, the University of Manitoba recently established The Gerry McDole Fellowship in Health Policy and Economic Growth. The Fellowship is intended to build capacity in health policy research as it relates to the links between health care and the Canadian economy. It will provide fellowship support to promising graduate students for exceptional contributions and innovations in health care that relate directly to economic growth.

Born and raised in Manitoba, Mr. McDole holds a Bachelor of Science degree and a Certificate of Business Management from the University of Manitoba, an MBA from Simon Fraser University, and a Business Administration diploma from the University of Toronto.

Mr. McDole's appointment to the Medicure Board of Directors is subject to regulatory approval.

About Medicure Inc.
Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine. The Company's lead drug, MC-1, is focused on the prevention and treatment of ischemia, ischemic reperfusion injury, and stroke. The cardiovascular and stroke market is the largest pharmaceutical sector with annual global sales of over US $70 billion.

The Company's second product candidate, MC-4232, is being targeted for the treatment of hypertension, a common disorder in which blood pressure remains abnormally high. Approximately 73% of the more than 50 million adult Americans who have hypertension, are not adequately treated.

Medicure also has a medicinal chemistry based Drug Discovery program focused on discovery and advancement of novel small molecule, anti-ischemics and anti-thrombotics towards human clinical studies.

This news release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Derek Reimer
Chief Financial Officer

Don Bain
Director of Investor & Public Relations

Medicure Inc.
888-435-2220
204-488-9823 fax
info@medicure.com

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