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January 28, 2004
Medicure Receives Approval for American Stock Exchange Listing

To begin trading February 17, 2004 under symbol MCU

WINNIPEG, Manitoba - (January 28, 2004) Medicure Inc. (TSX:MPH), a cardiovascular drug discovery and development company, is pleased to announce that it has received approval to list its common shares of the Company on the American Stock Exchange® (Amex®). Medicure shares are expected to commence trading on the Amex on February 17, 2004 under the ticker symbol MCU.

"The approval to list our stock on the Amex is an important milestone for the Company as it provides a second major trading market for our stock, thereby increasing market awareness for our shareholders," stated Albert D. Friesen, Ph.D., Medicure's President and Chief Executive Officer. "This United States listing will give Medicure increased visibility in the American marketplace and makes the Company significantly more accessible to U.S. investors.

"Our goal remains to increase exposure of our Company to institutional and retail investors who would otherwise be restricted from purchasing Medicure shares," Dr. Friesen added. "Broadening our investor base by establishing ourselves in the USA market, is beneficial to all shareholders."

About The American Stock Exchange
The American Stock Exchange® (Amex®) is the only primary exchange that offers trading across a full range of equities, options and exchange traded funds (ETFs), including structured products and HOLDRSsm. In addition to its role as a national equities market, the Amex is the pioneer of the ETF, responsible for bringing the first domestic product to market in 1993. Leading the industry in ETF listings, the Amex lists 124 ETFs. The Amex is also one of the largest options exchanges in the U.S., trading options on broad-based and sector indexes as well as domestic and foreign stocks. For more information, please visit www.amex.com.

About Medicure Inc.
Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine. The Company's lead drug, MC-1, is focused on the prevention and treatment of ischemia, ischemic reperfusion injury, and stroke. The cardiovascular and stroke market is the largest pharmaceutical sector with annual global sales of over US $70 billion.

The Company's second product candidate, MC-4232, is being targeted for the treatment of hypertension, a common disorder in which blood pressure remains abnormally high. Approximately 73% of the more than 50 million adult Americans who have hypertension, are not adequately treated.

Medicure also has a medicinal chemistry based Drug Discovery program focused on discovery and advancement of novel small molecule, anti-ischemics and anti-thrombotics towards human clinical studies.

This news release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Derek Reimer
Chief Financial Officer

Don Bain
Director of Investor & Public Relations

Medicure Inc.
888-435-2220
204-488-9823 fax
info@medicure.com

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