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December 2, 2005

MEDICURE ANNOUNCES PLANS TO RELEASE RESULTS FROM THE MEND-CABG STUDY

WINNIPEG, Manitoba Ð (December 2, 2005)

WINNIPEG , Manitoba – (December 2, 2005) Medicure Inc. (TSX:MPH; Amex: MCU), a cardiovascular drug discovery and development company today announced plans to release post operative day 30 (POD 30) results from MEND-CABG, the Company's Phase II clinical trial, on Monday morning, December 5, 2005. The MEND-CABG study is a double blinded, parallel group, randomized, placebo-controlled study evaluating Medicure’s FDA Fast Tracked cardioprotective product, MC-1, in 901 patients who underwent coronary artery bypass graft (CABG) surgery. The Company will hold a live investor presentation in New York to be made accessible via conference call and webcast, beginning at 8:00 am Eastern.

Investors are invited to attend the presentation at the New York Palace Hotel located at 455 Madison Avenue in the Holmes I room on the 4th floor.

Notification of Conference Call:

The investor presentation of the MEND-CABG results will be made available by conference call and webcast:

Date: Monday, December 5, 2005

Time: 8:00 am Eastern Time

Telephone: 1-800-591-6923 or 1-617-614-4907

Passcode: Medicure

Location: The Holmes 1 Room of The New York Palace Hotel, 455 Madison Avenue, New York

Webcast: Click here to access webacst

 

About MEND-CABG

The MEND-CABG trial is designed to evaluate the cardioprotective and neuroprotective effects of MC-1 in high-risk coronary artery disease patients undergoing CABG surgery. The Phase II study enrolled 901 patients at 42 investigational sites throughout Canada and the United States. The purpose of the study is to evaluate the efficacy of MC-1 in reducing the combined incidence of all vascular deaths, non-fatal myocardial infarction (heart attack) and non-fatal cerebral infarction (stroke), up to and including postoperative day 30 (POD 30).

About Medicure Inc.

Medicure Inc. is a cardiovascular drug discovery and development Company focused on developing effective therapeutics for unmet needs in the field of cardiovascular medicine, the largest pharmaceutical market sector. The Company's solid position in this field is supported by the following attributes:

  • Cardiovascular focused pipeline: a global market of over US $70 billion
  • Two drugs - MC-1 & MC-4232 - in advanced clinical development
  • Three positive Phase II trials completed
  • FDA Fast Track designation for MC-1
  • Unique products addressing major, inadequately served markets
  • Dual action antithrombotic, MC-45308, with positive preclinical results

Medicure also has a medicinal chemistry based Drug Discovery program focused on discovery and advancement of novel small molecule, anti-ischemics, and antithrombotics towards human clinical studies.

This press release contains forward-looking statements that involve risks, which may cause actual results to differ materially from the statements made, and accordingly may be deemed to be forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Such risks, include among others, those described in the Company’s annual return on Form 20-F. The forward-looking statements are made as of the date hereof, and the Company disclaims any intention and has no obligation or responsibility to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise.

For more information, please contact:

Derek Reimer
Chief Financial Officer

Hogan Mullally
Manager of Investor & Public Relations

Medicure Inc.
888-435-2220
204-488-9823 fax
info@medicure.com

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